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KMID : 4412620160220010013
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Clinical Hypertension
2016 Volume.22 No. 1 p.13 ~ p.13
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The role of abnormal metabolic conditions on arterial stiffness in healthy subjects with no drug treatment
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Hwang Hyo-Sang
Ko Kwang-Pil
Kim Myeong-Gun
Kim Si-Hun
Moon Jeong-Geun
Chung Wook-Jin
Shin Mi-Seung
Han Seung-Hwan
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Abstract
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Background: Subjects with abnormal metabolic conditions had increased risk for cardiovascular disease. We investigated the role of abnormal metabolic conditions on arterial stiffness in healthy subjects with no drug treatment.
Methods: A total 601 subjects (age 48.7?±?11.8 years, male 46.2 %, hypertension 19.1 %) were enrolled. Major cardiovascular risk factors, metabolic conditions and parameters (pre-diabetes, diabetes mellitus, metabolic syndrome, fasting blood sugar (FBS), glycated hemoglobin), lipid profiles, hsCRP, and brachial ankle pulse wave velocity (baPWV) were measured.
Results: Subjects with metabolic syndrome (n?=?200) had higher baPWV than in subjects without metabolic syndrome (n?=?401) even after adjustments for age, sex and presence of hypertension (1435.9?±?212.2 vs. 1336.5?±?225.0 cm/sec, p?
Conclusions: Subjects with abnormal metabolic conditions have increased arterial stiffness independent of age and BP which may contribute to the development of cardiovascular disease.
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KEYWORD
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Cardiovascular disease, Arterial stiffness, Metabolic syndrome, Diabetes mellitus
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