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KMID : 4412620190250010015
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Clinical Hypertension
2019 Volume.25 No. 1 p.15 ~ p.15
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Red cell distribution width and preeclampsia: a systematic review and meta-analysis
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Adam Ishag
Mutabingwa Theonest K.
Malik Elfatih M.
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Abstract
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Background: Preeclampsia is a serious pregnancy-related disease which may lead to adverse health effects to the mother and fetus. Besides many publications on the association of red cell distribution width (RDW) and preeclampsia, there has been no published meta-analysis. This necessitated the present systemic review and met-analysis to assess the RDW in relation to preeclampsia.
Methods: Preferred Reporting Items for Systematic Reviews and Meta-Analyses guideline was followed. Relevant published studies were searched in PubMed, Cochrane library, Google scholar, Scopus, Embase and CINAHL using the term “Preeclampsia OR eclampsia AND red cell distribution width OR red blood cells). Modified Newcastle ? Ottawa quality assessment scale was used for critical appraisal of retrieved studies. Pooled Meta logistic regression was computed using OpenMeta Analyst software. Subgroup and meta-regression methods were performed to analyse the heterogeneity.
Results: Eleven case control studies were included in the met-analyses with a total of 951 cases (preeclampsia) and 2024 controls. The mean (SD) of the RDW level was significantly higher in women with preeclampsia compared to controls [15.10 (2.48) % vs. 14.26(1.71) %, P?
Conclusion: RDW level was significantly higher in women with preeclampsia compared to controls. Similarly, women with severe preeclampsia had significantly higher RDW than those with the mild form.
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KEYWORD
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Preeclampsia, Pregnancy hypertension, Red cell distribution width, Meta-analysis, Sudan
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