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KMID : 4412620200260010015
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Clinical Hypertension
2020 Volume.26 No. 1 p.15 ~ p.15
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Association of MYH9-rs3752462 polymorphisms with chronic kidney disease among clinically diagnosed hypertensive patients: a case-control study in a Ghanaian population
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Owiredu William K. B. A.
Appiah Michael
Obirikorang Christian
Adu Evans Asamoah
Boima Vincent
Amos-Abanyie Ernestine Kubi
Akyaw Priscilla Abena
Owiredu Eddie-Williams
Acheampong Emmanuel
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Abstract
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Background: Chronic kidney disease (CKD) is a significant comorbidity among hypertensive patients. Polymorphisms in the non-muscle myosin heavy chain 9 gene (MYH9) have been demonstrated to be significantly associated with CKD, among African- and European-derived populations. We investigated the spectrum of MYH9-associated CKD among Ghanaian hypertensive patients.
Methods: The study constituted a total of 264 hypertensive patients. Hypertensive patients with glomerular filtration rate (eGFR)?
Results: The cases and control participants differed in terms of age, sex, family history, and duration of CKD (p-value
Conclusions: We have demonstrated that MYH9 polymorphisms exist among Ghanaian hypertensive patients and rs3752462 polymorphism of MYH9 is associated with CKD. This baseline indicates that further longitudinal and multi-institutional studies in larger cohorts in Ghana are warranted to evaluate MYH9 SNP as an independent predictor of CKD among hypertensive patients in Ghana.
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KEYWORD
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Chronic kidney disseise, Hypertension, Single nucleotide polymorphism, MYH9- rs3752462
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