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KMID : 4412620200260010019
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Clinical Hypertension
2020 Volume.26 No. 1 p.19 ~ p.19
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Serum adipocytokines and adiposity as predictive indices of preeclampsia
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Bawah Ahmed Tijani
Yeboah Francis Agyemang
Nanga Salifu
Alidu Huseini
Ngala Robert A.
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Abstract
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Background: This study was aimed at determining the levels of serum adiponectin, leptin, resistin, visfatin and lipids during the first trimester in pregnant women and to evaluate the relationship between these biochemical markers and preeclampsia (PE). Available evidence point to changes in the levels of these adipokines in PE hence this study examined the potential of using these biomarkers in the prediction of the disease.
Methods: This was a case-control study which compared first trimester serum biochemical and anthropometric parameters in pregnant women who subsequently developed PE and those who did not. Blood pressure and urine protein were determined after 20?weeks of gestation and diagnosis of PE performed according to the guidelines of the American Heart Association.
Results: There was no significant difference (p?>?0.05) in the lipid profile with the exception of HDL cholesterol which was significantly lower (p?=?0.043) in the PE group compared to the normotensive group. There were, however, significant differences (p?
Conclusion: Adiponectin, leptin, resistin and visfatin were found to be significant predictors of PE, with resistin being the best predictor after controlling for BMI. However, adiponectin was the best predictor after controlling for BMI, age, parity and family history of diabetes and preeclmapsia.
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KEYWORD
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Preeclampsia, Adiponectin, Leptin, Resistin, Visfatin
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